San Francisco 49ers at Los Angeles Rams Player Props, Picks and Predictions - 9/22/2024 4:25 PM EST

We have your San Francisco 49ers at Los Angeles Rams prop betting and game preview needs covered as the San Francisco 49ers hit the road to face the Los Angeles Rams.

San Francisco 49ers at Los Angeles Rams Odds Info

Best Moneyline Odds: San Francisco 49rs -350 (bet365) / LA Rams +280 (ESPN Bet)
Best Spread Odds: 7.5 - San Francisco 49ers -105 (bet365) / Los Angeles Rams -115 (bet365)
Best Total Odds: 43.5 - Under -105 (FanDuel) / Over -110 (DraftKings)

Game Info

Date: 9/22/2024
Time: 4:25 PM EST
Location: SoFi Stadium (Inglewood, CA)
TV: FOX

Historic Head-to-Head Stats and Analysis

Over the past three seasons, the San Francisco 49ers and the Los Angeles Rams have faced each other four times. In these matchups, the 49ers have emerged victorious in three games, while the Rams have won once. The visiting team has had the upper hand, winning three out of the four games. When it comes to covering the spread, both teams have managed to do so twice. The games have generally been high-scoring affairs, with the total score going over the set line in three instances and under just once. Key statistics from these games reveal that the 49ers have consistently outperformed the Rams in terms of total yards and rushing yards, while the Rams have shown strength in passing yards and third-down conversions.

The most recent encounter between these two teams took place on January 7, 2024, where the Rams narrowly defeated the 49ers with a 21-20 victory. The game was characterized by a strong start from the 49ers, who led 20-7 at halftime, thanks to touchdowns from Elijah Mitchell and Ronnie Bell. However, the Rams mounted a comeback in the second half, with Carson Wentz connecting with Tyler Johnson and scoring a rushing touchdown himself. A successful two-point conversion pass to Tutu Atwell sealed the win for the Rams. Despite the loss, the 49ers outgained the Rams in total yards, recording 300 compared to the Rams' 258. Both teams had one turnover, with the Rams' Wentz throwing an interception and the 49ers losing a fumble.

In terms of individual game statistics, the Rams' offense was more efficient in the passing game, completing 70.8% of their passes compared to the 49ers' 61.5%. The Rams also excelled in third-down conversions, achieving a 60% success rate, while the 49ers managed 50%. On the ground, the 49ers had a slight edge, averaging 4.31 yards per rushing attempt compared to the Rams' 3.03. Defensively, the Rams recorded three sacks, while the 49ers managed two. Penalties were a factor, with the 49ers incurring five penalties for 78 yards, whereas the Rams were penalized twice for just eight yards. This game highlighted the Rams' ability to capitalize on key moments, ultimately leading to their narrow victory.

San Francisco 49ers at Los Angeles Rams Preview

The San Francisco 49ers and Los Angeles Rams are set to clash in a pivotal NFC West matchup at SoFi Stadium. Both teams are grappling with significant injuries, which could heavily influence the outcome of this contest. The 49ers, coming off a narrow 23-17 loss to the Minnesota Vikings, are dealing with the absence of key offensive playmakers. Deebo Samuel, who has been a vital component of their offense, is sidelined with a calf strain, while Christian McCaffrey is on injured reserve due to Achilles tendinitis and a calf strain. Despite these setbacks, the 49ers have shown resilience, with quarterback Brock Purdy stepping up in the passing game, supported by tight end George Kittle and wide receiver Brandon Aiyuk.

On the other side, the Rams are reeling from a 41-10 defeat at the hands of the Arizona Cardinals. The loss was compounded by the injury to star wide receiver Cooper Kupp, who is expected to miss several weeks with an ankle injury. The Rams' offensive line has been a revolving door due to injuries, with multiple starters either on injured reserve or playing through pain. This has put additional pressure on veteran quarterback Matthew Stafford, who has struggled to find consistency amid the chaos.

Defensively, the 49ers have been solid, but they will need to adjust without Samuel and McCaffrey, focusing on containing the Rams' passing attack, which has been bolstered by the emergence of rookie wide receiver Marvin Harrison Jr. The Rams, meanwhile, will look to exploit any weaknesses in the 49ers' secondary, especially if strong safety Talanoa Hufanga is unable to return from injury.

As both teams aim to overcome their injury woes, the 49ers appear to have a slight edge due to their depth and recent success against the Rams. However, the Rams will be desperate to avoid an 0-3 start, making this a must-watch game for fans of both teams.

San Francisco 49ers at Los Angeles Rams Pick: San Francisco 49ers Moneyline

The San Francisco 49ers are poised to secure a victory against the Los Angeles Rams, and the moneyline pick for the 49ers is well-supported by several compelling factors. Despite both teams grappling with significant injuries, the 49ers have demonstrated resilience and depth, which gives them a distinct advantage in this matchup. The Rams are reeling from a 41-10 defeat to the Arizona Cardinals, a game that exposed their vulnerabilities, particularly on the offensive line and in their receiving corps. With star wide receiver Cooper Kupp sidelined due to an ankle injury and Puka Nacua also out, the Rams' passing game is severely hampered. This places immense pressure on quarterback Matthew Stafford, who has struggled to find consistency amid a revolving door of offensive linemen due to injuries.

Conversely, the 49ers, while missing key offensive playmakers like Deebo Samuel and Christian McCaffrey, have shown they can adapt. Quarterback Brock Purdy has stepped up, supported by reliable targets such as tight end George Kittle and wide receiver Brandon Aiyuk. The 49ers' defense remains a formidable force, capable of containing the Rams' offense, which has been further weakened by the absence of Kupp and the ongoing issues on the offensive line.

Historically, the 49ers have had the upper hand in recent matchups against the Rams, winning three of their last four encounters. This trend, combined with the Rams' current injury woes and the 49ers' ability to perform under pressure, makes the 49ers a strong pick for the moneyline. The 49ers' depth and adaptability, coupled with the Rams' struggles, particularly in protecting Stafford and maintaining a consistent offensive rhythm, suggest that San Francisco is well-positioned to capitalize on these weaknesses and secure a crucial victory at SoFi Stadium.

San Francisco 49ers at Los Angeles Rams Top Player Prop Picks

Brock Purdy Over 250.5 Passing Yards Passing Yards -110 (DraftKings)

Brock Purdy has shown resilience and adaptability in the face of adversity, stepping up for the 49ers despite the absence of key offensive playmakers like Deebo Samuel and Christian McCaffrey. In the recent game against the Minnesota Vikings, Purdy threw for 319 yards, demonstrating his ability to lead the offense effectively. With the Rams' secondary weakened by injuries, including the absence of starting cornerback Darious Williams, Purdy is well-positioned to exploit these vulnerabilities. The Rams' defense has struggled, allowing 41 points to the Cardinals, and with Purdy's growing chemistry with targets like George Kittle and Brandon Aiyuk, he is likely to surpass the 250.5 passing yards mark.

Matthew Stafford Under 1.5 Passing Touchdowns Passing Touchdowns +120 (FanDuel)

Matthew Stafford faces a challenging matchup against a formidable 49ers defense that has been solid despite their own injury woes. The Rams' offensive line has been a revolving door due to injuries, and with star wide receiver Cooper Kupp sidelined, Stafford's options are limited. In the recent loss to the Cardinals, Stafford was under constant pressure, resulting in five sacks and a fumble. The 49ers' defense, known for its ability to apply pressure, will likely capitalize on the Rams' weakened offensive line, making it difficult for Stafford to find the end zone multiple times. With the Rams' passing game further hampered by the absence of Puka Nacua, Stafford is expected to struggle to reach two passing touchdowns.

George Kittle Over 4.5 Receptions Receptions -115 (bet365)

With Deebo Samuel sidelined, George Kittle is poised to play a more prominent role in the 49ers' passing attack. Kittle has been a reliable target for Brock Purdy, and his ability to find openings in the defense will be crucial against a Rams team that has shown vulnerabilities in their secondary. The Rams' defense allowed Cardinals' rookie Marvin Harrison Jr. to have a breakout game, indicating potential gaps that Kittle can exploit. Given the 49ers' need to adapt without Samuel and McCaffrey, Kittle's involvement is expected to increase, making the over on 4.5 receptions a strong play.