Baltimore Orioles @ San Diego Padres Player Props, Picks and Predictions - 9/3/2025 4:10 PM EDT

We have your Baltimore Orioles @ San Diego Padres prop betting and game preview needs covered as the Baltimore Orioles hit the road to face the San Diego Padres.

Baltimore Orioles @ San Diego Padres Pick

Best Moneyline Odds: San Diego Padres -164 (FanDuel), Baltimore Orioles +145 (BetRivers)
Best Spread Odds: San Diego Padres -1.0 (-118 DraftKings), Baltimore Orioles +1.5 (-142 FanDuel)
Best Total Odds: Over 8.0 (-118 DraftKings), Under 8.5 (-115 BetMGM)

Game Info

Date: 2025-09-03
Time: 4:10 PM EDT
Location: Petco Park, San Diego
TV: SDPA

Baltimore Orioles @ San Diego Padres Preview

The Baltimore Orioles (62-76, 5th in AL East) are on the road to face the San Diego Padres (76-62, 2nd in NL West) in the final game of their three-game series. The Orioles enter this matchup having won the first two games of the series, securing victories of 6-2 and 4-3. While the Orioles have struggled recently with a 3-7 record in their last 10 games, they've shown resilience in San Diego, holding a 4-2 record in their last six visits. The Padres, conversely, are looking to halt a skid, having lost their last two games and seven of their last nine overall. They boast a strong home record of 43-23 this season.

On the mound, the Orioles will send left-hander Cade Povich (2-7, 5.04 ERA) to the hill. Povich has shown flashes of potential, including a solid five-inning, two-run outing against Boston in his last start. For the Padres, left-hander Nestor Cortes (2-3, 5.06 ERA) will take the mound. Despite a similar season ERA to Povich, Cortes has a historically strong record against the Orioles, holding a 5-1 career record with a 2.20 ERA in 11 appearances, striking out 72 batters in 57.1 innings. The Padres' pitching staff as a whole has been impressive this season, ranking second in the league with a 3.65 ERA and holding opponents to a league-best .224 batting average.

Offensively, the Orioles have been powered by players like Jeremiah Jackson, who is on a 13-game hitting streak and has been hitting .333 with four home runs and 17 RBIs in his last 29 games. Gunnar Henderson also provides pop with 16 home runs and a .279 batting average. For the Padres, Manny Machado leads the team with 21 home runs and 79 RBIs, while Ramón Laureano has added 22 homers. Luis Arraez has also been a consistent threat, going 3-for-4 with an RBI in a recent game against the Orioles. Petco Park is generally considered a pitcher-friendly park, ranking 24th in overall park factor, though it plays slightly above average for home runs.

Historic Head-to-Head Stats and Analysis

The Baltimore Orioles have had the upper hand in recent head-to-head matchups against the San Diego Padres. The Orioles have won their last three head-to-head meetings, including the first two games of this current series (6-2 and 4-3 victories). In 2025, the Orioles are 2-0 against the Padres. Historically, the Orioles are 4-2 in their last six visits to San Diego. Looking at the total runs, the Over has hit in 7 of the last 11 head-to-head contests between these two teams.

Pick: San Diego Padres Moneyline

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Despite dropping the first two games of this series, the San Diego Padres are poised to bounce back and secure a win in the finale. The primary reason for this confidence lies with starting pitcher Nestor Cortes. While his season ERA is 5.06, Cortes has an exceptional career track record against the Baltimore Orioles, boasting a 5-1 record with a dominant 2.20 ERA over 11 appearances. He has consistently stifled Orioles hitters, striking out 72 batters in 57.1 innings. The Padres also hold a significant home-field advantage, with a strong 43-23 record at Petco Park this season. Sharp betting data indicates a 60.32% sharp win percentage on the Padres moneyline, suggesting that professional bettors are backing San Diego to close out the series with a victory. Given Cortes's historical dominance over Baltimore and the Padres' strong performance at home, the San Diego Padres moneyline at -164 (FanDuel) is the recommended pick.

Top Player Prop Picks

Jeremiah Jackson (Baltimore Orioles) - Hits Over 0.5

Jeremiah Jackson has been a revelation for the Orioles, extending his hitting streak to 13 games and showcasing impressive form. He has hit the over on 0.5 hits in 100% of his last 5 games and 100% of his last 1