Week 5 of the NFL featured games that you needed to watch to the end. We saw a few comebacks, including the Broncos scoring 11 unanswered points in the fourth quarter to give the Eagles their first loss of the season. We also saw Cam Ward get his first NFL win as he led the Titans from a 21-3 deficit against the Cardinals to win 22-21.

Parity is what makes the NFL competitive, and with the Eagles and Bills losing this past week, there are no more unbeaten teams. A team that is now grabbing the attention of the league is the Jaguars. They are riding a league-high three-game winning streak, which includes coming out on top of a close battle with the Chiefs.

Even with the loss to the Patriots last week, Josh Allen (+150) remains the favorite to take home his second MVP. Patrick Mahomes’ (+550) loss to the Jaguars didn’t hurt his chances, but a new contender has moved in as Baker Mayfield’s (+650) impressive start to the season puts him not far behind.

NFL Week 6 Preview

Week 6 includes several matchups that could turn out to be exciting.

It begins on Thursday with an NFC East matchup between the Giants and Eagles. This will be Giants rookie QB Jaxson Dart’s biggest test to date, as he takes on the defending champions.

Sunday features several matchups to pay attention to. The Jaguars will take their winning streak and host the Seahawks, who are having a good start to their season at 3-2. Even without Brock Purdy, the 49ers keep winning, but this week they face a challenge as they head to Tampa Bay to take on the Buccaneers. Sunday concludes with the Lions, riding their four-game winning streak at Arrowhead, facing the Chiefs, who, at 2-4, are almost in desperation mode.

The weekend ends with a doubleheader on Monday night, featuring the Falcons hosting the Bills, and the Bears trying to avenge their heartbreaking loss to the Commanders on that Hail Mary last season.

BetSmart Player Prop Finder

The BetSmart package has been helping bettors increase their bankroll throughout the NFL season. With trackers for Arbitrage Bets, Positive EV, and Middle Bets, you have a wide variety of high-percentage wagers to choose from.

It also features the popular Prop Finder tool, which provides detailed insights into all of the best available props. Each prop has data, including its positive EV percentage, the sportsbook with the best odds, and the frequency with which the player has hit the number in the last 5, 10, and 15 games.

The BetSmart Prop Finder currently has valuable data for hundreds of player prop lines in NFL Week 6.

Here are 5 to consider:

1. A.J. Brown

Game: Philadelphia Eagles vs. New York Giants
Date: Thursday, October 9 @ 8 p.m. ET
Prop: Total Rushing & Receiving Under 65.5
Odds: -115
Sportsbook(s): Hard Rock
Trends: 80% in Last 5, 70% in Last 10

2. Rachaad White

Game: San Francisco 49ers vs. Tampa Bay Buccaneers
Date: Sunday, October 11 @ 4:25 p.m. ET
Prop: Total Rushing & Receiving Yards Under 80.5
Odds: -115
Sportsbook(s): Hard Rock, BetMGM
Trends: 100% in Last 5, 90% in Last 10

3. Tony Pollard

Game: Tennessee Titans vs. Las Vegas Raiders
Date: Sunday, October 11 @ 4:05 p.m. ET
Prop: Total Rushing Attempts Over 13.5
Odds: -125
Sportsbook(s): BetMGM
Trends: 100% in Last 5, 80% in Last 10

4. Isiah Pacheco

Game: Detroit Lions vs. Kansas City Chiefs
Date: Sunday, October 5 @ 8:20 p.m. ET
Prop: Total Rushing & Receiving Under 48.5
Odds: -114
Sportsbook(s): FanDuel
Trends: 80% in Last 5, 90% in Last 10

5. Bijan Robinson

Game: Buffalo Bills vs. Atlanta Falcons
Date: Monday, October 13 @ 7:15 p.m. ET
Prop: Total Rushing & Receiving Over 108.5
Odds: -115
Sportsbook(s): Hard Rock
Trends: 100% in Last 5, 70% in Last 10

Props & Middle Betting Opportunities

Betting on props with a strong likelihood to win based on recent trends is a smart strategy, and you can also make middle bets across different player prop markets.

Many props, such as Rushing Attempts, offer an excellent opportunity to profit from Middle Bets. If one sportsbook has a player’s Rushing Attempts set at 12.5 and another at 14.5, you bet the over 12.5 and under 14.5. This guarantees you hit at least one of these bets, but if the final number is either 13 or 14, you win both.

With the Pickwatch Most Profitable Markets tool, the Total Rushing Attempts prop market has consistently generated solid betting opportunities every week during the 2025 NFL season, offering a positive ROI.

Here is some data provided by the tool:

Last 7 Days: 83% ROI
Last 14 Days: 56% ROI
Last 30 Days: 68% ROI

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