The unpredictability of NFL Week 5 was proven by the successes of Underdogs, which went 9-5 Against the Spread AND Straight Up.

It started right away with the depleted San Francisco 49ers, at +8.5, beating the Rams outright in Overtime at SoFi Stadium, and concluded with Jacksonville covering the 3.5 and winning a thrilling Monday Night contest at home against Kansas City. If you've been following our Expert Picks, you'd see that many Experts were all over the Jaguars at home.

As for Totals bets, they have been even more challenging this season. Even the most savvy of experts are struggling to be above .500 betting on Totals; Overs went 9-5 in Week 5 and the market continues to be volatile.

Finding value here can be difficult. However, there are some shrewd betting approaches that look beyond the final score, with consistent profitability lately in partial-game totals in halves or quarters.

Betting Markets to Keep an Eye on in NFL Week 6

Here are some of the most promising betting opportunities for this week’s slate of NFL games:

1. Underdogs

The Pickwatch weekly feature column Upset Watch was 5-0 on Underdog selections in Week 6. They correctly picked the Jaguars over the Chiefs, the Broncos over the Eagles, Tampa Bay beating Seattle, the Pats topping the Bills, and the Commanders defeating the Chargers.

With the dogs barking in the NFL lately, be sure to check out the Week 6 Upset Watch column, as Underdogs will surely be bets to consider.

NOTE: To view Upset Watch, you’ll need either an Expert or BetSmart subscription.

2. Partial Game Totals

With the Pickwatch Most Profitable Markets tool, I was able to easily identify the highest-return opportunities across all leagues and bet types. This allows you to see which props have the best win percentage and return on investment (ROI) over the last 7 Days, 14 Days, or 30 days.

While full-game Totals have been tough to bet this season, there are two partial-game Totals markets that have had great success over the past month, and should be considered this weekend:

2nd Half Totals - Middles
- Last 30 Days ROI - 83%
3rd Quarter Totals - Positive EV
- Last 30 Days ROI - 82%

NOTE: While the Most Profitable Markets tool is available to everyone, you must have BetSmart to use the Positive EV Tool and Middle Bets Tracker.

3. Player Props

BetSmart's Prop Finder tool gives you immediate access to valuable data for hundreds of NFL prop bets, spanning everything from pass completions and rushing yards to anytime touchdown scorers.

This tool allows you to explore a vast range of markets across numerous sportsbooks. You can easily refine your search by filtering for game, player, date, and outcome, and then sorting the results by odds, fair probability, and relevant trends to find your edge.

With the data from the Prop Finder, there are several player props that are worth taking in Week 6.

4. Arbitrage Bets

You can currently find several available Arbitrage opportunities with the Arbitrage Bet Tracker. With a FREE BetSmart trial, you’ll get instant access to see these, and lock in guaranteed profit.

With a BetSmart subscription, Pickwatch streamlines your betting strategy by scanning all major sportsbooks to instantly pinpoint profitable arbitrage opportunities, where you bet opposite sides of a mispriced market at two different sportsbooks. With the Notification feature, you'll receive instant alerts, enabling you to capitalize on guaranteed profit before lines move.

BetSmart Free Trial + Promo

You can find all of these profitable betting options, Expert Picks and much more by signing up for a BetSmart 14-Day Free Trial. You’ll get immediate access to several new sports betting tools that will help you wager wisely during the NFL season.