Here is the Pickwatch BetSmart Preview for the Buffalo Bills vs. Atlanta Falcons in Week 6 of the 2025 NFL Season.

Buffalo Bills vs. Atlanta Falcons Game Info

Date: Monday, October 13, 2025
Time: 7:15 PM ET
Location: Mercedes-Benz Stadium — Atlanta, Georgia
TV: ESPN

Buffalo Bills vs. Atlanta Falcons Betting Odds

Point Spread
- Bills -3.5
- Falcons +3.5
Moneyline
- Bills -205
- Falcons +172
Total
- Over 49.5
- Under 49.5

*Odds via FanDuel

Season Betting Records

Moneyline
- Bills: 4-1
- Falcons: 2-2
Against the Spread
- Bills: 2-3
- Falcons: 2-2
Totals (Over-Under)
- Bills: 3-2
- Falcons: 1-3

Buffalo Bills (4–1) @ Atlanta Falcons (2–2) Preview

Buffalo is looking to rebound from a 23-20 home loss to New England, and they’ll need a strong showing in Atlanta tonight to stay atop the AFC East. The Falcons, meanwhile, are coming off a bye and get some reinforcements, including cornerback A.J. Terrell expected to return — a boost to a secondary tested by fast receivers.

The Falcons’ defense faces a tall order in trying to contain Josh Allen, who’s operated as both passer and runner this year. Atlanta’s pass rush must be sharper, and they’ll need to keep Allen off balance with pressure and disguised coverages. For Atlanta’s offense, Michael Penix Jr. must manage the pocket, avoid turnovers, and make plays in the intermediate passing game.

This game likely hinges on turnover differential, third-down efficiency, and red zone execution. Buffalo’s edge is in offensive versatility and depth; Atlanta’s chance lies in leveraging home-field and defensive disruptions. Many models lean Bills −4.5 tonight, with a 49.5 total pointing toward a moderately high-scoring affair.

Bills/Falcons Head-to-Head (H2H) Stats and Analysis

The Atlanta Falcons lead the all-time series 7-6 vs. the Buffalo Bills. Here are the last 5 games:

Buffalo Bills 29, Atlanta Falcons 15 — January 2, 2022
Buffalo Bills 23, Atlanta Falcons 17 — October 1, 2017
Atlanta Falcons 34, Buffalo Bills 31 (OT) — December 1, 2013
Atlanta Falcons 31, Buffalo Bills 3 — December 27, 2009
Atlanta Falcons 24, Buffalo Bills 16 — September 25, 2005

BetSmart Betting Rundown

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Arbitrage

Our Arbitrage Betting Tool is currently identifying 1 arbitrage betting opportunity for guaranteed profit. Odds and lines change often, however, so be sure to check back, as more arbitrage opportunities could still become available before kickoff.

Middles

Our Middle Betting Tool is currently identifying 2 middle betting opportunities. Odds and lines change often, however, so be sure to check back, as more middle bet opportunities could still become available before kickoff.

Positive EV

Our Positive EV Betting Tool has identified 2 different positive expected value wagers, and provided data on the expected value percentrage, suggested Kelly Stake, and how often the bet has hit in the last 5, 10 and 15 games.

Player Props

Our Prop Finder Tool has identified 44 different player prop bets, and provided data on how often each player has hit the specific prop in the last 5, 10 and 15 games.

Bills vs. Falcons: Expert Picks

Visit our Expert Picks page to view picks and data from over 200 experts to see where the consensus is on the Bills vs. Falcons moneyline, point spread and total points.