Here is the Pickwatch BetSmart Preview for the Buffalo Bills vs. Houston Texans game in Week 12 of the 2025 NFL Season.

Buffalo Bills vs. Houston Texans Game Info

Date: Thursday, November 20, 2025
Time: 8:15 PM ET
Location: NRG Stadium — Houston, Texas
TV: Prime Video / Amazon Prime Video

Bills vs. Texans Betting Odds

Point Spread
- Bills -5.5
- Texans +5.5
Moneyline
- Bills -270
- Texans +230
Total
- Over/Under 43.5

Season Betting Records

Moneyline
- Bills: 7-3
- Texans: 5-5
Against the Spread
- Bills: 5-5
- Texans: 4-6
Totals (Over-Under)
- Bills: 5-5
- Texans: 3-6-1

Buffalo Bills (7–3) @ Houston Texans (5–5) Preview

Buffalo is riding high after a 44-32 victory where QB Josh Allen accounted for six total touchdowns, showing both his passing and rushing prowess. ([turn0news10]) Despite this offensive surge, the Bills will be without TE Dalton Kincaid (hamstring), WRs Curtis Samuel (elbow/neck) and Mecole Hardman (calf), which will test their depth and alignment in key situations.

Houston, meanwhile, boasts the NFL’s top-ranked defense this season—first in scoring and total defense—but faces a critical challenge in slowing Allen and limiting Buffalo’s big-play scoring capability. ([turn0news12]) The Texans will again start Davis Mills under center as franchise QB C.J. Stroud remains out with a concussion.

Key matchups: Bills’ rushing attack (led by Allen’s dual threat plus RB James Cook) vs. Texans run defense, which has been elite. Houston must force turnovers and control tempo to stay in this game. The spread around −6 and low total of 43.5 reflect a market expectation that Buffalo will win, but the Texans’ home-underdog streak vs. Buffalo (5-0 home wins vs Bills in recent history) and their defensive strength inject value into the +6 line.

The Bills must travel south for the first time this season where they haven’t been favored as often; winning on the road has been less frequent, so execution early and limiting mistakes will be crucial. Houston’s path to upset lies in dominating time of possession, limiting explosive plays by Buffalo, and getting Mills to manage the game effectively under pressure.

Bills/Texans Head-to-Head (H2H) Stats and Analysis

The Buffalo Bills lead the all-time series 7-5 vs. the Houston Texans. Here's their last 5 games:

Houston Texans 23, Buffalo Bills 20 — October 6, 2024
Buffalo Bills 40, Houston Texans 0 — October 3, 2021
Houston Texans 22, Buffalo Bills 19 — January 4, 2020 (OT)
Houston Texans 20, Buffalo Bills 13 — October 14, 2018
Buffalo Bills 30, Houston Texans 21 — December 6, 2015

BetSmart Betting Rundown

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NOTE: All available bets are as of time of publication. Odds and lines change often, so be sure to check each subsequent Pickwatch betting tool for the latest numbers.

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Bills vs. Texans: Expert Picks

Visit our Expert Picks page to view picks and data from over 200 experts to see where the consensus is on the Bills vs. Texans moneyline, point spread and total points.