Arizona Cardinals at San Francisco 49ers Player Props, Picks and Predictions - 10/6/2024 4:05 PM EST

We have your Arizona Cardinals at San Francisco 49ers prop betting and game preview needs covered as the Arizona Cardinals hit the road to face the San Francisco 49ers.

Arizona Cardinals at San Francisco 49ers Odds Info

Best Moneyline Odds: Arizona Cardinals +280 (BetMGM) / San Francisco 49rs -350 (BetMGM)
Best Spread Odds: -7.0 - Arizona Cardinals -105 (DraftKings) / San Francisco 49ers -115 (DraftKings)
Best Total Odds: 49.5 - Under -105 (ESPN BET) / Over -110 (bet365)

Game Info

Date: 10/6/2024
Time: 4:05 PM EST
Location: Levi's Stadium (Santa Clara, CA)
TV: FOX

Historic Head-to-Head Stats and Analysis

Over the past three seasons, the San Francisco 49ers and the Arizona Cardinals have faced off four times, with the 49ers emerging victorious in all encounters. The games have been evenly split between home and away victories, with each team winning twice on the road. In terms of betting outcomes, the 49ers have consistently outperformed expectations, covering the spread in all four matchups, while the Cardinals have failed to do so. Additionally, each of these games has seen the total score exceed the over-under line, resulting in four consecutive overs. This trend highlights the offensive capabilities of both teams when they meet, as well as potential defensive vulnerabilities.

The most recent game between these two teams took place on December 17, 2023, with the 49ers defeating the Cardinals 45-29. The 49ers were the favorites with a closing spread of -11.5 and successfully covered it. The game saw a high total score of 74 points, significantly surpassing the closing over-under of 48.5. San Francisco's offense was efficient, accumulating 406 total yards and converting all four red zone opportunities into touchdowns. Brock Purdy led the 49ers with 242 passing yards and four touchdowns, while Christian McCaffrey contributed with both rushing and receiving touchdowns. The Cardinals, despite gaining 436 total yards, were hindered by two interceptions thrown by Kyler Murray and managed only two successful red zone conversions out of three attempts.

In the broader context of these matchups, the 49ers have consistently demonstrated superior offensive execution and defensive resilience. Across the four games, San Francisco has averaged 39 points per game, while Arizona has averaged 17 points. The 49ers' ability to capitalize on scoring opportunities, as evidenced by their high red zone efficiency, has been a key factor in their success. Conversely, the Cardinals have struggled with turnovers, particularly interceptions, which have often shifted momentum in favor of the 49ers. As these teams prepare to meet again, the historical data suggests that the 49ers have had the upper hand in recent years, both in terms of outright victories and against-the-spread performance.

Arizona Cardinals at San Francisco 49ers Preview

The Arizona Cardinals are set to face the San Francisco 49ers in a crucial NFC West showdown at Levi's Stadium. The Cardinals, currently holding a 1-3 record, are coming off a disappointing 42-14 loss to the Washington Commanders. This defeat marked their second consecutive home loss, highlighting ongoing struggles in both their offensive and defensive units. Despite these setbacks, the Cardinals have shown resilience in their rushing attack, ranking fifth in the NFL with an average of 153.3 rushing yards per game. However, their passing game has been inconsistent, with quarterback Kyler Murray heavily reliant on rookie wide receiver Marvin Harrison Jr., who has been a bright spot with four touchdowns in the last three games.

On the other side, the San Francisco 49ers, with a 2-2 record, are looking to build on their momentum following a commanding 30-13 victory over the New England Patriots. The 49ers have demonstrated offensive prowess, averaging 413.3 yards per game, which ranks them second in the league. Quarterback Brock Purdy has been efficient, particularly in red zone situations, and the return of key players like Deebo Samuel and George Kittle has bolstered their offensive lineup. However, the 49ers are dealing with injury concerns, notably with All-Pro linebacker Fred Warner and defensive tackle Jordan Elliott, both of whom are day-to-day with ankle injuries.

Historically, the 49ers have dominated this matchup, winning the last four encounters against the Cardinals. San Francisco's defense has been a significant factor in these victories, consistently limiting Arizona's scoring opportunities and capitalizing on turnovers. As the Cardinals aim to reverse their fortunes, they will need to address their defensive vulnerabilities, particularly against a 49ers team that has excelled in exploiting such weaknesses. The game promises to be a test of Arizona's ability to adapt and overcome their recent challenges, while San Francisco will look to maintain their winning streak and keep pace in the competitive NFC West.

Arizona Cardinals at San Francisco 49ers Pick: San Francisco 49ers Moneyline

The San Francisco 49ers are poised to continue their dominance over the Arizona Cardinals in this Week 5 matchup, making the 49ers moneyline a compelling pick. Historically, the 49ers have had the upper hand in this rivalry, winning the last four meetings against the Cardinals, each by a significant margin. This trend is supported by their recent performances, where the 49ers have consistently outperformed expectations, covering the spread in all four encounters and showcasing their offensive prowess.

San Francisco's offense, led by quarterback Brock Purdy, has been firing on all cylinders, averaging 413.3 yards per game, which ranks them second in the NFL. The return of key offensive players like Deebo Samuel and George Kittle has further strengthened their lineup, making them a formidable force against a struggling Cardinals defense. In their most recent victory over the New England Patriots, the 49ers demonstrated their ability to capitalize on scoring opportunities, converting all four red zone chances into touchdowns.

On the defensive side, while the 49ers are dealing with some injury concerns, notably with Fred Warner and Jordan Elliott, their overall defensive unit has been resilient. They have consistently limited Arizona's scoring opportunities in past matchups, forcing turnovers and maintaining a strong defensive front. The Cardinals, on the other hand, have been plagued by inconsistencies, particularly in their passing game, and have struggled to find reliable options beyond rookie wide receiver Marvin Harrison Jr.

Given the 49ers' recent form, their historical success against the Cardinals, and the current state of both teams, San Francisco is well-positioned to secure another victory. The 49ers' ability to exploit Arizona's defensive vulnerabilities and their proven track record in this matchup make the moneyline pick for San Francisco a sound choice.

Arizona Cardinals at San Francisco 49ers Top Player Prop Picks

Brock Purdy Over 1.5 Passing TDs -135 (bet365)

Brock Purdy has been a key component of the San Francisco 49ers' offensive success, particularly in red zone situations. In their recent victory over the New England Patriots, Purdy threw for four touchdowns, showcasing his ability to efficiently lead the offense and capitalize on scoring opportunities. With the return of key offensive weapons like Deebo Samuel and George Kittle, Purdy is well-positioned to continue his strong performance against a Cardinals defense that has struggled to contain opposing quarterbacks. The Cardinals have allowed multiple passing touchdowns in recent games, and with Purdy's current form, the over on 1.5 passing touchdowns is a compelling choice.

Kyler Murray Over 30.5 Rushing Yards -105 (bet365)

Kyler Murray's mobility is a crucial aspect of his game, and with the Cardinals' passing attack facing challenges, his rushing ability becomes even more significant. Murray has consistently used his legs to extend plays and gain crucial yardage, especially when his primary receiving targets are covered. The 49ers' defense, while strong, is dealing with injuries to key players like Fred Warner, which could open up opportunities for Murray to exploit gaps and accumulate rushing yards. Given the 49ers' recent struggles against mobile quarterbacks, Murray's over on 30.5 rushing yards presents a favorable prop bet.

Deebo Samuel Over 52.5 Receiving Yards -110 (bet365)

Deebo Samuel's return to the 49ers' lineup has provided a significant boost to their offensive capabilities. Known for his versatility and playmaking ability, Samuel is a constant threat in both the receiving and rushing game. In the 49ers' recent win over the Patriots, Samuel's presence was felt as he contributed to the team's offensive success. Facing a Cardinals defense that has shown vulnerabilities in the secondary, Samuel is poised to have a productive outing. With the 49ers' offense firing on all cylinders and Samuel's ability to break big plays, the over on 52.5 receiving yards is a strong pick.