Chicago White Sox @ Detroit Tigers Player Props, Picks and Predictions - 9/5/2025 6:40 PM EDT

We have your Chicago White Sox @ Detroit Tigers prop betting and game preview needs covered as the Chicago White Sox hit the road to face the Detroit Tigers.

Chicago White Sox @ Detroit Tigers Pick

Best Moneyline Odds: Detroit Tigers -180 (BetRivers) / Chicago White Sox +160 (Fanduel)
Best Spread Odds: Detroit Tigers -1.0 (-136) (BetRivers) / Chicago White Sox +1.5 (-130) (Caesars)
Best Total Odds: Over 8.5 (-102) (BetMGM) / Under 8.5 (-115) (ESPN BET)

Game Info

Date: 2025-09-05
Time: 6:40 PM EDT
Location: Comerica Park
TV: -

Chicago White Sox @ Detroit Tigers Preview

The Detroit Tigers (81-60) are set to host the Chicago White Sox (53-88) at Comerica Park in an American League Central matchup. The Tigers are currently in a strong position in the playoff race, while the White Sox have been eliminated from contention. Detroit's offense ranks 11th in MLB, showcasing a strong performance recently, including their best hitter boasting a .500 batting average and a 1.217 OPS over the past week. In contrast, the White Sox offense ranks 28th in the league, struggling to generate consistent runs.

On the mound, the Tigers will start Jack Flaherty (7-13, 4.74 ERA). Despite his record, advanced statistics rank him as the 46th best starting pitcher in MLB, with a 3.70 xFIP suggesting he may have been unlucky this season. Flaherty averages 6.6 strikeouts per game, which could be a key factor against Chicago's struggling lineup. For the White Sox, Shane Smith (4-7, 3.81 ERA) will take the mound. Smith's 4.49 xFIP indicates potential for regression, and he's projected to pitch less effectively, averaging just 4.9 innings and allowing 1.7 walks.

Comerica Park is generally considered a slightly hitter-friendly venue with a 1.039 run factor, but its spacious dimensions (420 feet to center field) tend to suppress home runs, indicated by a 0.928 home run factor. This could benefit both pitchers in tonight's game, especially those who induce ground balls.

Historic Head-to-Head Stats and Analysis

The Detroit Tigers have held a significant advantage over the Chicago White Sox this season, boasting a 7-3 head-to-head record. This dominance suggests the Tigers are simply the more talented team across various aspects of the game. Furthermore, the White Sox have struggled against the Tigers following a win, losing seven of their last eight games in such scenarios. The total has also trended towards the under in recent matchups, with the under hitting in seven of the last ten meetings between these two teams. Tigers' starter Jack Flaherty has been particularly effective against the White Sox, allowing only 3 runs combined in his previous two starts against them this season.

Pick: Detroit Tigers Moneyline

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The Detroit Tigers are a strong pick on the moneyline for this matchup. Their impressive 81-60 record and comfortable position in the playoff race highlight their superior overall performance compared to the White Sox (53-88). The Tigers hold a significant 7-3 head-to-head advantage against Chicago this season, demonstrating their consistent dominance. Sharp money is heavily backing the Tigers on the moneyline, with a 62.88% sharp win percentage. At home, the Tigers have a solid 45-27 record, and they are 59-35 when playing as favorites. While the moneyline price is steep, the combination of home-field advantage, a superior bullpen (Detroit's bullpen ERA is 3.41 compared to Chicago's 5.12), and Jack Flaherty's past success against the White Sox makes Detroit the favored side. Flaherty's 3.70 xFIP suggests he's due for better results, and his ability to generate strikeouts against a struggling White Sox offense should limit their scoring opportunities. Despite the White Sox's recent four-game sweep of the Twins, this game presents a challenging regression spot against a more talented Tigers team.

Top Player Prop Picks

Riley Greene Over 1.5 Hits+Runs+RBIs

Riley Greene has been an offensive force for the Tigers, emerging as a legitimate AL MVP candidate. He's hitting .269 with 32 home runs and 103 RBIs this season. Against right-handed pitchers like Shane Smith, Greene has been particularly potent, posting a .291/.368/.581 slash line with 23 of his 32 home runs coming against righties. He has also hit safely in 15 of his last 17 games against the White Sox. His ability to drive the ball to all fields, combined with his clutch performance with runners in scoring position (.312 batting average), makes him a strong candidate to exceed 1.5 Hits+Runs+RBIs. You can find this prop at -125.

Jack Flaherty Over 6.5 Strikeouts

Jack Flaherty, the Tigers' starting pitcher, averages 6.6 strikeouts per game, aligning perfectly with this prop line. Despite his win-loss record, Flaherty's advanced metrics suggest he's a better pitcher than his ERA indicates, and he has a history of striking out batters. He faces a White Sox lineup that ranks 28th in offensive production, which should provide ample opportunities for him to rack up strikeouts. Given his strikeout upside and the White Sox's offensive struggles, Flaherty is well-positioned to go over 6.5 strikeouts. This prop is available at +110.

Kerry Carpenter Over 1.5 Total Bases

Kerry Carpenter has been a key contributor to the Tigers' offense. In their most recent game, he went 1 for 3 with a home run and three RBIs. Carpenter has a prop for over 1.5 total bases at -105. His ability to hit for power, as evidenced by his recent home run, makes him a strong candidate to achieve multiple bases in this game. Against a White Sox pitching staff that has struggled, Carpenter should have opportunities to connect for extra-base hits or multiple singles to clear this line.