Chicago White Sox @ Minnesota Twins Player Props, Picks and Predictions - 9/1/2025 2:10 PM EDT

We have your Chicago White Sox @ Minnesota Twins prop betting and game preview needs covered as the Chicago White Sox hit the road to face the Minnesota Twins.

Chicago White Sox @ Minnesota Twins Pick

Best Moneyline Odds: Minnesota Twins -188 on Fanduel
Best Spread Odds: Minnesota Twins -1.5 (+110) on ESPN BET
Best Total Odds: Over 9.0 (-110) on Caesars

Game Info

Date: September 1, 2025
Time: 2:10 PM EDT
Location: Target Field, Minneapolis, MN
TV: MNNT

Chicago White Sox @ Minnesota Twins Preview

The Minnesota Twins (62-74) are set to host the Chicago White Sox (49-88) at Target Field in an American League Central division clash. Both teams have struggled with consistency this season, each holding a 4-6 record over their last ten games. The Twins are coming off a solid 7-2 victory against the San Diego Padres, highlighted by a dominant pitching performance from Joe Ryan and a home run from Byron Buxton. The White Sox, meanwhile, snapped a losing streak with a narrow 3-2 win over the New York Yankees, with key home runs from Lenyn Sosa and Colson Montgomery.

On the mound for the Twins will be right-hander Bailey Ober (4-7, 5.14 ERA). While Ober has faced a challenging stretch, going 0-6 with a 5.83 ERA in his last 15 starts, his career numbers against the White Sox are encouraging, boasting a 6-2 record with a 3.43 ERA across 14 starts. The White Sox were initially slated to start Aaron Civale, but he was claimed off waivers. Journeyman Bryse Wilson (0-2, 6.95 ERA in 19 appearances) is now the likely fill-in, having struggled earlier in the season before being sent to Triple-A.

Offensively, the Twins are led by Byron Buxton, who recently hit his 29th home run of the season, surpassing his previous career high. Buxton has a strong track record against the White Sox, making him a key player to watch. The Twins rank 12th in the league in home runs. For the White Sox, Lenyn Sosa is having a breakout season, hitting .269 with 18 home runs and 61 RBIs, and has shown improved plate discipline. The White Sox bullpen has been a bright spot, ranking 6th in the league for fewest blown saves.

Both teams are dealing with injuries. The Twins have several players on the IL, including key pitchers Pablo López and David Festa, and position players Christian Vázquez and Alan Roden. The White Sox are without Luis Robert Jr. (strained left hamstring) and Miguel Vargas (sprained left hand).

Historic Head-to-Head Stats and Analysis

The rivalry between the Chicago White Sox and Minnesota Twins has a rich history. The Twins hold a significant edge in the all-time series, boasting 115 head-to-head victories, with 74 of those coming at home. The White Sox have secured 91 wins, with approximately half of them occurring on the road. More recently, the Twins have dominated this matchup at home, winning 14 of their last 15 head-to-head contests against the White Sox at Target Field. While the White Sox did win 3 of their last 4 meetings against the Twins, the Twins had won the four meetings prior to that stretch, indicating a back-and-forth dynamic but a clear home advantage for Minnesota.

Pick: Minnesota Twins Moneyline

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The Minnesota Twins are the clear pick on the moneyline for this matchup. Despite their overall struggles this season, the Twins have a significant historical advantage when playing the White Sox at home, winning 14 of their last 15 home games against them. This strong home performance against Chicago is a compelling factor. Furthermore, the Twins are sending Bailey Ober to the mound, who, despite a recent winless streak, has a favorable career record against the White Sox (6-2, 3.43 ERA). The White Sox, on the other hand, are likely to start Bryse Wilson, who has a high ERA of 6.95 this season. The Twins' offense, led by the red-hot Byron Buxton, who has a history of success against the White Sox, should be able to capitalize on Wilson's struggles. My model projects a 5-4 victory for the Twins, and sharp money is heavily backing Minnesota with a 62.47% sharp win percentage on the moneyline. NumberFire also predicts a Twins win with a 65.4% probability.

Top Player Prop Picks

Byron Buxton Over 1.5 Total Bases

Byron Buxton is in excellent form, having recently hit his 29th home run of the season, surpassing his previous career high. He has a remarkable track record against the White Sox, with 23 career home runs against them in 96 games, which is significantly more than against any other opponent. Facing White Sox likely starter Bryse Wilson, who has struggled this season, and playing at Target Field, which is slightly batter-friendly, sets Buxton up for success. His ability to hit for power means a single extra-base hit would cover this line, and a home run would easily clear it. The odds for this prop are +100.

Trevor Larnach Over 0.5 RBI

Trevor Larnach has a favorable matchup against White Sox likely starter Bryse Wilson. While the sample size is small, Larnach has shown good contact and power against right-handed pitching, including a home run against Aaron Civale in a previous encounter. With Byron Buxton hitting ahead of him and getting on base, Larnach will have opportunities to drive in runs. The Twins' offense has shown flashes of power, and against a struggling pitcher, Larnach is in a good position to contribute. The odds for this prop are +145.

Lenyn Sosa Over 0.5 Hits

Lenyn Sosa is having a breakout season for the White Sox, batting .269 with 18 home runs and 61 RBIs. His manager has praised his improved plate discipline, which has contributed to his success. While facing Twins starter Bailey Ober, Sosa has a decent historical performance against right-handed pitching. Given his consistent hitting this season and recent form, getting at least one hit in this game is a strong possibility. The odds for this prop are -240.