Here is the Pickwatch BetSmart Preview for the Cincinnati Bengals vs. Denver Broncos in Week 4 of the 2025 NFL Season.

Bengals vs. Broncos Game Info

Date: Monday, September 29, 2025
Time: 8:15 PM ET (5:15 PM PT)
Location: Empower Field at Mile High — Denver, Colorado
TV: ESPN / ABC (Monday Night Football)

Bengals vs. Broncos Betting Odds

Point Spread
- Bengals +7.5 (-108)
- Broncos -7.5 (-112)
Moneyline
- Bengals +350
- Broncos -450
Total
- Over 44.5 (-108)
- Under 44.5 (-112)

*Odds via FanDuel

Cincinnati Bengals (2–1) @ Denver Broncos (1–2) Preview

The Bengals are coming off a brutal 48–10 loss to the Vikings, and now must travel to Denver to face a Broncos team desperate to rebound. Denver, meanwhile, lost on a late field goal to the Chargers and needs this win to stay relevant.

Cincinnati will be missing TE Noah Fant (concussion), forcing more targets onto Mike Gesicki and other receivers. The Broncos may be without Marvin Mims Jr. (hip) — listed as questionable — which could dull their vertical passing threat.

The altitude and weather in Denver could favor an under game — dry, cool, with wind at altitude suppressing some deep passes. The market has leaned heavily toward Broncos -7.5, showing sharp confidence in Denver covering at home.

Head-to-Head Stats and Analysis

Their most recent matchup was last season in Cincinnati, which the Bengals won 36-33. The Broncos lead the all-time series, 22-12.

Bengals 30, Broncos 24 (2024)
Bengals 15, Broncos 10 (2021)
Broncos 24, Bengals 10 (2018)
Bengals 20, Broncos 17 (2017)
Broncos 29, Bengals 17 (2016)

BetSmart Betting Rundown

The Pickwatch BetSmart subscription package provides valuable sports betting tools that will help you wager wisely on the Bengals vs. Broncos game and start building bankroll. Sign up for a 14-Day Free Trial today and get instant access to our proprietary tools and data.

Arbitrage

Our Arbitrage Betting Tool identified 3 arbitrage betting opportunities for guaranteed profit. The tool scans all major sportsbooks in real-time, so be sure to check back often as odds and lines change often, and an arbitrage opportunity could become available before kickoff.

Middles

Our Middle Betting Tool has identified 36 different middle betting opportunities, some of which are among the Most Profitable Markets so far this season.

Positive EV

Our Positive EV Betting Tool has identified 10 different positive expected value wagers, and provided data on the expected value percentrage, suggested Kelly Stake, and how often the bet has hit in the last 5, 10 and 15 games.

Player Props

Our Prop Finder Tool has identified 153 different player prop bets, and provided data on how often each player has hit the specific prop in the last 5, 10 and 15 games. Here's some props you can get data on:

Bo Nix Total Passing Yards: Over/Under 218.5
Chase Brown Total Rushing Attempts: Over/Under 15.5
Ja'Marr Chase Total Receptions: Over/Under 5.5

Season Betting Records

Moneyline
- Bengals: 2-1
- Broncos: 1-2
Against the Spread
- Bengals: 1-2
- Broncos: 0-2-1
Totals (Over-Under)
- Bengals: 2-1
- Broncos: 1-2

Bengals vs. Broncos: Expert Picks

Visit our Expert Picks page to view picks and data from over 200 experts to see where the consensus is on the Bengals vs. Broncos moneyline, point spread and total points.