Kansas City Chiefs at San Francisco 49ers Player Props, Picks and Predictions - 10/20/2024 4:25 PM EST

We have your Kansas City Chiefs at San Francisco 49ers prop betting and game preview needs covered as the Kansas City Chiefs hit the road to face the San Francisco 49ers.

Kansas City Chiefs at San Francisco 49ers Odds Info

Best Moneyline Odds: Kansas City Chiefs +100 (bet365) / San Francisco 49ers -120 (bet365)
Best Spread Odds: -1.5 - Kansas City Chiefs -110 (BetMGM) / San Francisco 49ers -110 (BetMGM)
Best Total Odds: 47.5 - Under -110 (FanDuel) / 47.0 - Over -108 (BetRivers)

Game Info

Date: 10/20/2024
Time: 4:25 PM EST
Location: Levi's Stadium (Santa Clara, CA)
TV: FOX

Historic Head-to-Head Stats and Analysis

In the past three seasons, the Kansas City Chiefs and the San Francisco 49ers have faced each other once, with the Chiefs emerging victorious. This game took place on October 23, 2022, with Kansas City as the visiting team. The Chiefs won the game, covering the spread as the favorite, while the 49ers, playing at home, did not cover. The game went over the set over-under line, marking the only instance in this period where the total score exceeded the expected points. The Chiefs' victory was decisive, with a final score spread of 21 points, highlighting their dominance in this matchup.

The most recent game between these two teams saw the Kansas City Chiefs defeat the San Francisco 49ers with a final score of 44-23. The Chiefs, favored with a closing spread of -1.5, covered the spread comfortably. Kansas City's offense was prolific, amassing 529 total yards, with Patrick Mahomes leading the passing attack with 423 yards and three touchdowns. Mecole Hardman was a standout performer, scoring three touchdowns, including two rushing and one receiving. The Chiefs' defense also played a crucial role, recording five sacks and two interceptions. Despite the 49ers' efforts, including a 15-yard touchdown reception by George Kittle, they were unable to keep pace with the Chiefs' high-powered offense.

In terms of team statistics, the Chiefs demonstrated efficiency on third downs, converting 66.67% of their attempts, while the 49ers converted 57.14%. Kansas City also had a slight edge in rushing yards, with 112 compared to San Francisco's 101. Both teams had an equal number of rushing attempts, but the Chiefs averaged more yards per attempt. Turnovers were a factor, with the Chiefs committing two and the 49ers three. The Chiefs' ability to capitalize on these opportunities contributed to their victory. The game was marked by a high total score of 67 points, significantly surpassing the closing over-under line of 48.5, indicating a game dominated by offensive plays.

Kansas City Chiefs at San Francisco 49ers Preview

The Kansas City Chiefs and San Francisco 49ers are set to clash in a highly anticipated Week 7 matchup at Levi's Stadium, a rematch of last season's Super Bowl LVIII. The Chiefs, led by the dynamic duo of Patrick Mahomes and Travis Kelce, come into this game undefeated at 5-0, having had the benefit of a bye week to rest and prepare. Despite not being at their peak form, the Chiefs have managed to maintain their winning streak, showcasing their resilience and depth.

On the other side, the 49ers, with a 3-3 record, are looking to build on their recent victory over the Seattle Seahawks. This game is crucial for San Francisco, not only to improve their standing in the NFC West but also to overcome the psychological hurdle of defeating a team that has been a thorn in their side in recent years. The 49ers have struggled against the Chiefs, particularly with Mahomes at the helm, and are eager to prove they can compete with the league's elite.

San Francisco's defense, anchored by Nick Bosa, will be tasked with containing Mahomes and the high-powered Chiefs offense. Bosa, who has been vocal about the importance of this game, will need to lead a defensive effort that can disrupt Mahomes' rhythm and limit big plays. Meanwhile, the 49ers' offense, led by quarterback Brock Purdy, will look to exploit any weaknesses in the Chiefs' defense, which has been formidable this season.

Rookie standout Dominick Puni will face a significant test against the Chiefs' defensive stalwart Chris Jones. Puni's performance could be pivotal in providing Purdy with the protection needed to execute Kyle Shanahan's offensive game plan. The 49ers will also rely on their playmakers, including Deebo Samuel and George Kittle, to generate explosive plays and keep pace with Kansas City's potent attack.

With both teams having much at stake, this matchup promises to be a thrilling encounter. The 49ers are favored by a slim margin, reflecting the confidence oddsmakers have in their ability to leverage home-field advantage. As the 49ers aim to hand the Chiefs their first loss of the season, fans can expect a high-scoring affair, reminiscent of their previous encounters, where offensive fireworks were on full display.

Kansas City Chiefs at San Francisco 49ers Pick: Total Points Over

The upcoming clash between the Kansas City Chiefs and the San Francisco 49ers is poised to be a high-scoring affair, making the over on the total points a compelling pick. Historically, when these two teams meet, offensive fireworks are often on display. In their most recent encounter, the Chiefs triumphed over the 49ers with a decisive 44-23 victory, a game that saw the total score soar well above the set over-under line. This trend of high-scoring games is likely to continue given the offensive capabilities of both teams.

The Chiefs, led by the prolific Patrick Mahomes, have consistently demonstrated their ability to put up points, even when not firing on all cylinders. With Mahomes at the helm, the Chiefs' offense is a formidable force, capable of exploiting any defensive lapses. The presence of Travis Kelce further bolsters their offensive arsenal, ensuring that Kansas City can strike quickly and often. Despite their undefeated record, the Chiefs have shown vulnerabilities on defense, which the 49ers will look to exploit.

On the other side, the 49ers, under the guidance of Kyle Shanahan, have an offense that can match the Chiefs' firepower. Quarterback Brock Purdy has been effective in orchestrating the 49ers' attack, supported by dynamic playmakers like Deebo Samuel and George Kittle. The 49ers' ability to generate explosive plays was evident in their recent victory over the Seattle Seahawks, where they put up 36 points. With both teams possessing potent offenses and the 49ers eager to prove themselves against a top-tier opponent, the stage is set for a high-scoring showdown.

Moreover, the 49ers' defense, while strong, will face a significant challenge in containing Mahomes and the Chiefs' high-octane offense. This could lead to a back-and-forth contest where both teams trade scores, further pushing the total points over the line. Given the offensive talent on display and the stakes involved in this Super Bowl rematch, betting on the total points to go over is a strategic choice that aligns with the historical and current dynamics of these two teams.

Kansas City Chiefs at San Francisco 49ers Top Player Prop Picks

Brock Purdy Over 248.5 Passing Yards -110 (bet365)

Brock Purdy has been a revelation for the San Francisco 49ers, leading an offense that has shown the ability to put up significant yardage, especially in high-stakes games. With the Chiefs' defense being formidable, Purdy will need to be at his best to keep pace with Patrick Mahomes and the high-powered Kansas City offense. The 49ers' recent performances suggest that Purdy is more than capable of surpassing the 248.5 passing yards mark, particularly with the likes of Deebo Samuel and George Kittle as his primary targets. Given the Chiefs' tendency to engage in shootouts, as evidenced by their previous high-scoring encounters, Purdy is likely to air it out frequently, making the over on his passing yards a strong play.

George Kittle Over 48.5 Receiving Yards -115 (Caesars)

George Kittle remains a crucial component of the 49ers' offensive scheme, and his ability to make big plays will be essential against a Chiefs defense that has been tested by elite tight ends in the past. Kittle's knack for finding seams in the defense and his chemistry with Purdy make him a prime candidate to exceed the 48.5 receiving yards line. In a game where the 49ers will need to exploit every offensive opportunity to keep up with Kansas City's scoring prowess, Kittle's role as a reliable target in the passing game is likely to be emphasized. His past performances against top-tier defenses further bolster the case for taking the over on his receiving yards.

Brandon Aiyuk Over 61.5 Receiving Yards -110 (bet365)

Brandon Aiyuk has emerged as a key playmaker for the 49ers, and his ability to beat man coverage will be tested against the Chiefs' secondary, which often relies on such schemes. Aiyuk's speed and route-running precision make him a formidable threat, especially in a matchup where the 49ers will need to stretch the field to keep the Chiefs' defense honest. With the Chiefs likely to focus on containing Deebo Samuel and George Kittle, Aiyuk could find himself in favorable matchups, allowing him to surpass the 61.5 receiving yards line. His potential to break off long receptions adds further value to the over on this prop, as the 49ers look to exploit every opportunity to gain yardage through the air.