Here is the Pickwatch BetSmart Preview for the Kansas City Chiefs vs. Jacksonville Jaguars in Week 5 of the 2025 NFL Season.

Kansas City Chiefs vs. Jacksonville Jaguars Game Info

Date: Monday, October 6, 2025
Time: 8:15 PM ET
Location: EverBank Stadium — Jacksonville, Florida
TV: ABC / ESPN

Chiefs vs. Jaguars Betting Odds

Point Spread
- Chiefs -3.5
- Jaguars +3.5
Moneyline
- Chiefs -190
- Jaguars +160
Total
- Over 45.5
- Under 45.5

*Odds via FanDuel

Season Betting Records

Moneyline
- Chiefs: 2-2
- Jaguars: 3-1
Against the Spread
- Chiefs: 2-2
- Jaguars: 3-1
Totals (Over-Under)
- Chiefs: 2-2
- Jaguars: 2-2

Kansas City Chiefs (2–2) @ Jacksonville Jaguars (3–1) Preview

Jacksonville, off to a surpising 3-1 start, has been riding an impressive turnover margin (+9) and stout defensive performances in their wins, and will hope to put Kansas City’s offense under pressure Monday night. The Chiefs, meanwhile, have rebounded after a disappointing 0–2 start with two straight wins led by Patrick Mahomes.

The matchup of Chiefs’ offensive firepower vs Jaguars’ ball control and defense will likely decide the tone. Betting markets have leaned Chiefs −3.5 with 45.5 total, pointing to a moderately close game.

Key injuries to monitor: Kansas City has downgraded WR Xavier Worthy to questionable (ankle), while Jacksonville’s DE Travon Walker might be a game-time decision after wrist surgery. If Walker’s limited, KC’s edge in pass protection could matter.

Chiefs/Rams Head-to-Head (H2H) Stats and Analysis

The Kansas City Chiefs lead the all-time series 10-6 over the Jacksonville Jaguars. Here are last 5 matchups:

Chiefs 17, Jaguars 9 — September 17, 2023
Chiefs 27, Jaguars 20 — January 21, 2023
Chiefs 27, Jaguars 17 — November 13, 2022
Chiefs 40, Jaguars 26 — September 8, 2019
Chiefs 30, Jaguars 14 — October 7, 2018

BetSmart Betting Rundown

The Pickwatch BetSmart subscription package provides valuable sports betting tools that will help you wager wisely on the Chiefs vs. Jaguars game and start building bankroll. Sign up for a 14-Day Free Trial today and get instant access to our proprietary tools and data.

Arbitrage

Our Arbitrage Betting Tool has identified 2 arbitrage betting opportunities for guaranteed profit.

Middles

Our Middle Betting Tool has identified 23 different middle betting opportunities, some of which are among the Most Profitable Markets so far this season.

Positive EV

Our Positive EV Betting Tool has identified 21 different positive expected value wagers, and provided data on the expected value percentrage, suggested Kelly Stake, and how often the bet has hit in the last 5, 10 and 15 games.

Player Props

Our Prop Finder Tool has identified 200 different player prop bets, and provided data on how often each player has hit the specific prop in the last 5, 10 and 15 games. Here's some props you can get data on:

Patrick Mahomes Total Passing Yards: Over/Under 250.5
Travis Kelce Total Receiving Yards: Over/Under 42.5
Travis Hunter Total Receptions Yards: Over/Under 3.5

Chiefs vs. Jaguars: Expert Picks

Visit our Expert Picks page to view picks and data from over 200 experts to see where the consensus is on the Chiefs vs. Jaguars moneyline, point spread and total points.