Oklahoma State Cowboys @ Oregon Ducks Player Props, Picks and Predictions - 9/6/2025 3:30 PM EDT

We have your Oklahoma State Cowboys @ Oregon Ducks prop betting and game preview needs covered as the Oklahoma State Cowboys hit the road to face the Oregon Ducks.

Oklahoma State Cowboys @ Oregon Ducks Pick

Best Moneyline Odds: Oregon Ducks -4500 (Caesars), Oklahoma State Cowboys +1800 (BetMGM)
Best Spread Odds: Oregon Ducks -27.5 (-115) (Caesars)
Best Total Odds: Over 58.5 (-110) (Caesars)

Game Info

Date: 2025-09-06
Time: 3:30 PM EDT
Location: Autzen Stadium, Eugene, Oregon
TV: CBS

Oklahoma State Cowboys @ Oregon Ducks Preview

The Oregon Ducks enter this Week 2 matchup as a formidable force, fresh off a dominant 59-13 victory over Montana State in their season opener. Quarterback Dante Moore was efficient and effective, completing 18 of 23 passes for 213 yards and three touchdowns, showcasing the Ducks' high-powered offense. Oregon's offensive line also earned an elite 93.0 pass blocking grade from Pro Football Focus in Week 1, highlighting their strength upfront. Under Coach Dan Lanning, the Ducks have consistently improved and are now considered a national championship contender, with their odds rising after their impressive start.

On the other side, the Oklahoma State Cowboys secured a 27-7 win against UT Martin, but their performance was less convincing compared to Oregon's blowout. The Cowboys are looking to bounce back from a challenging 2024 season where they finished 2-10 overall and winless in Big 12 play. Adding to their challenges, starting quarterback Hauss Hejny is sidelined with a broken foot, meaning backup Zane Flores is expected to lead the offense. While Oklahoma State's defense showed some pressure in their opener, they face a significant step up in competition against the Ducks. Head Coach Mike Gundy's position is reportedly under scrutiny, adding pressure to the team's performance.

Historic Head-to-Head Stats and Analysis

The most recent head-to-head contest between these two programs occurred on December 29, 2021, where the Oregon Ducks defeated the Oklahoma State Cowboys with a final score of 47-32.

Pick: Oregon Ducks -27.5 Spread

Oregon's dominant Week 1 performance against Montana State showcased their offensive firepower and efficiency, with quarterback Dante Moore looking sharp and their offensive line excelling in pass blocking. In contrast, Oklahoma State struggled to put away their FCS opponent, UT Martin, in a less convincing 27-7 win, and will be without their starting quarterback Hauss Hejny due to injury, relying on backup Zane Flores. The Ducks are a national championship contender, while the Cowboys are coming off a difficult 2024 season and are considered a significant underdog. While a 27.5-point spread is substantial, Oregon's talent advantage, home-field advantage, and strong early-season form make them a strong candidate to cover against a struggling Oklahoma State team.