New England Patriots at San Francisco 49ers Player Props, Picks and Predictions - 9/29/2024 4:05 PM EST

We have your New England Patriots at San Francisco 49ers prop betting and game preview needs covered as the New England Patriots hit the road to face the San Francisco 49ers.

New England Patriots at San Francisco 49ers Odds Info

Best Moneyline Odds: New England Patriots +425 (bet365) / San Francisco 49rs -530 (BetRivers)
Best Spread Odds: -10.5 - New England Patriots -120 (ESPN BET) / San Francisco 49ers +100 (ESPN BET)
Best Total Odds: 39.5 - Under -110 (BetRivers) / Over -110 (BetRivers)

Game Info

Date: 9/29/2024
Time: 4:05 PM EST
Location: Levi's Stadium (Santa Clara, CA)
TV: FOX

New England Patriots at San Francisco 49ers Preview

The New England Patriots are set to face the San Francisco 49ers in a Week 4 matchup that presents a significant challenge for both teams. The Patriots, coming off a disheartening 24-3 loss to the New York Jets, are struggling offensively, having scored only one touchdown in their last seven quarters. Their offensive line woes have been glaring, allowing seven sacks and 15 quarterback hits in their last outing. With a 1-2 record, the Patriots are in dire need of a turnaround, but they face a formidable opponent in the 49ers, who, despite their own struggles, remain a strong team.

The 49ers, also at 1-2, have been hit hard by injuries to key players. Defensive tackle Javon Hargrave is out with a partial triceps tear, and offensive stars Christian McCaffrey, Deebo Samuel, and George Kittle are all sidelined with various injuries. Quarterback Brock Purdy is dealing with back soreness, though his MRI came back mostly clean, and he is expected to play. Despite these setbacks, the 49ers have shown resilience, with players like Jordan Mason and Jauan Jennings stepping up in the absence of their star teammates.

San Francisco's recent loss to the Los Angeles Rams was a tough pill to swallow, especially after leading by double digits. However, the 49ers have a history of bouncing back, and with the Patriots' current form, they have a prime opportunity to do so. The Patriots' defense, led by Raekwon McMillan and Jahlani Tavai, will need to be at their best to contain the 49ers' offense, which, even without its stars, has the potential to be explosive.

As both teams look to improve their standings, this game promises to be a test of depth and adaptability. The 49ers, playing at home, will aim to leverage their home-field advantage and depth to secure a much-needed victory, while the Patriots will be looking to defy the odds and pull off an upset.

New England Patriots at San Francisco 49ers Pick: San Francisco 49ers Moneyline

In this intriguing Week 4 matchup, the San Francisco 49ers are poised to secure a victory against the New England Patriots, despite the challenges posed by injuries to key players. The 49ers, playing at home, have a significant advantage, not only due to their home-field presence but also because of their depth and resilience. While the absence of stars like Christian McCaffrey, Deebo Samuel, and George Kittle is notable, the 49ers have demonstrated their ability to adapt, with players such as Jordan Mason and Jauan Jennings stepping up impressively. Jennings, in particular, had a standout performance against the Rams, amassing 175 yards and three touchdowns, showcasing the team's offensive potential even without its top players.

Moreover, the Patriots are struggling significantly on the offensive front. Their recent 24-3 loss to the New York Jets highlighted glaring issues, particularly with their offensive line, which allowed seven sacks and 15 quarterback hits. This vulnerability is likely to be exploited by the 49ers' defense, which, despite missing Javon Hargrave, remains formidable. The Patriots' offensive woes are compounded by their inability to score, having managed only one touchdown in their last seven quarters, and ranking last in total yards and passing yards per game.

While the 49ers have had a rocky start to the season, their losses have been narrow, and they have shown the capability to lead games, as evidenced by their early dominance against the Rams. With quarterback Brock Purdy expected to play despite back soreness, the 49ers have the leadership needed to guide them to victory. Purdy's impressive performance against the Rams, where he threw for 292 yards and three touchdowns, underscores his ability to lead the team effectively.

Given the Patriots' current form and the 49ers' depth and adaptability, San Francisco is well-positioned to capitalize on their home advantage and secure a win. The odds favor the 49ers, and with their track record of bouncing back, they are the clear choice for the moneyline pick in this matchup.

New England Patriots at San Francisco 49ers Top Player Prop Picks

Jauan Jennings Over 75.5 Receiving Yards Prop (+110) (FanDuel)

Jauan Jennings has emerged as a key offensive weapon for the 49ers, especially in the absence of Deebo Samuel and George Kittle. In the recent game against the Rams, Jennings showcased his potential by amassing 175 yards and three touchdowns on 11 catches. With the Patriots' defense struggling, as evidenced by their recent performance against the Jets where they allowed 400 total yards, Jennings is poised to have another standout game. The Patriots' secondary will have their hands full, and Jennings' ability to exploit defensive lapses makes the over on his receiving yards an attractive proposition.

Brock Purdy Over 1.5 Passing Touchdowns Prop (-120) (DraftKings)

Brock Purdy has been a bright spot for the 49ers, even amidst their injury woes. His performance against the Rams, where he threw for 292 yards and three touchdowns, underscores his capability to lead the offense effectively. Despite dealing with back soreness, Purdy's MRI came back mostly clean, and he is expected to play. The Patriots' defense, which allowed the Jets to dominate in their last outing, will likely struggle to contain Purdy, especially with the 49ers' depth at receiver. Given Purdy's recent form and the Patriots' defensive vulnerabilities, betting on him to throw over 1.5 touchdowns is a solid choice.

Jordan Mason Over 50.5 Rushing Yards Prop (-105) (BetMGM)

With Christian McCaffrey sidelined, Jordan Mason has stepped up as a reliable option in the 49ers' backfield. The Patriots' defense, which has shown weaknesses, particularly in their recent loss to the Jets, presents an opportunity for Mason to shine. The 49ers will likely lean on their running game to control the tempo, and Mason's ability to find gaps in the defense makes the over on his rushing yards a compelling bet. As the 49ers aim to bounce back from their recent setbacks, Mason's role will be crucial, and he is well-positioned to exceed expectations on the ground.