San Francisco 49ers at Arizona Cardinals Player Props, Picks and Predictions - 1/5/2025 4:25 PM EST

We have your San Francisco 49ers at Arizona Cardinals prop betting and game preview needs covered as the San Francisco 49ers hit the road to face the Arizona Cardinals.

San Francisco 49ers at Arizona Cardinals Odds Info

Best Moneyline Odds: San Francisco 49ers +178 (Caesars) / Arizona Cardinals -210 (BetRivers)
Best Spread Odds: -4.5 - San Francisco 49ers -110 (FanDuel) / -4.0 - Arizona Cardinals -108 (DraftKings)
Best Total Odds: 43.0 - Under -110 (bet365) / 42.5 - Over -115 (Caesars)

Game Info

Date: 1/5/2025
Time: 4:25 PM EST
Location: State Farm Stadium (Glendale, AZ)
TV: FOX

Historic Head-to-Head Stats and Analysis

Over the past two seasons, the San Francisco 49ers and the Arizona Cardinals have faced each other three times. In these matchups, the 49ers emerged victorious twice, while the Cardinals secured one win. The visiting team has won two of these encounters, with the home team winning once. Against the spread, the 49ers have covered twice, and the Cardinals have covered once. The total score has gone over the set line in two of the games, while it went under in one. These games have showcased a mix of outcomes, with both teams having moments of dominance and resilience.

The most recent game between the two teams took place on October 6, 2024, where the Arizona Cardinals narrowly defeated the San Francisco 49ers with a score of 24-23. The Cardinals, who were the underdogs with a closing spread of +7.5, managed to win both the game and against the spread. The game saw a strong start from the Cardinals with a 50-yard rushing touchdown by Kyler Murray, but the 49ers responded with a field goal and a touchdown pass to George Kittle. Despite a blocked field goal returned for a touchdown by Deommodore Lenoir, the Cardinals managed to claw back with a combination of field goals and a crucial two-point conversion run by James Conner. The Cardinals sealed their victory with a late 35-yard field goal by Chad Ryland.

In terms of statistics, the 49ers accumulated 384 total yards and 22 first downs, while the Cardinals recorded 358 total yards and 19 first downs. Both teams struggled with turnovers, with the 49ers committing three (two interceptions and one fumble) and the Cardinals one interception. The Cardinals' rushing game was particularly effective, averaging 6.5 yards per attempt, while the 49ers averaged 5.88 yards per rushing attempt. The Cardinals' defense also played a crucial role, securing two interceptions and allowing only one passing touchdown. Despite the 49ers' higher total yardage, the Cardinals' strategic plays and key conversions ultimately led them to victory.

San Francisco 49ers at Arizona Cardinals Preview

The San Francisco 49ers and Arizona Cardinals are set to face off in a Week 18 matchup that, while devoid of playoff implications, promises to be an intriguing contest. Both teams have been eliminated from postseason contention, with the 49ers sitting at 6-10 and the Cardinals at 7-9. Despite the lack of stakes, the game offers a chance for both squads to end their seasons on a positive note.

The 49ers will be without their starting quarterback, Brock Purdy, who is sidelined with a right elbow contusion and nerve inflammation. In his place, Joshua Dobbs will take the helm. Dobbs, who has experience with the Cardinals, brings mobility to the quarterback position, which could be crucial given the 49ers' injury-riddled offensive line. His ability to scramble and extend plays will be tested against a Cardinals defense that has shown resilience throughout the season.

For the Cardinals, this game represents an opportunity to sweep the season series against the 49ers for the first time since 2021. Arizona's head coach, Jonathan Gannon, has emphasized the importance of finishing the season strong, and a win would double their victory total from the previous year. The Cardinals' offense, led by a dynamic rushing attack, will look to exploit a 49ers defense that has been hampered by injuries.

In their previous encounter, the Cardinals edged out a narrow victory over the 49ers, showcasing their ability to capitalize on key moments. With both teams eager to end the season on a high note, fans can expect a competitive game filled with strategic plays and potential surprises. As the 49ers and Cardinals take the field, the focus will be on execution and resilience, setting the stage for an entertaining conclusion to their respective seasons.

San Francisco 49ers at Arizona Cardinals Pick: Total Points Over

As the San Francisco 49ers prepare to face the Arizona Cardinals in their season finale, the expectation is for a high-scoring affair, making the over on the total points an enticing pick. Both teams have shown the ability to put points on the board, and the circumstances surrounding this matchup suggest a continuation of that trend.

The 49ers, despite their struggles this season, have demonstrated offensive prowess, particularly in their recent games. In their last outing against the Detroit Lions, they managed to score 34 points, showcasing their ability to find the end zone even amidst a challenging season. With Joshua Dobbs stepping in as the starting quarterback, the 49ers gain a mobile playmaker who can extend plays and create scoring opportunities, especially against a Cardinals defense that has been resilient but not impenetrable.

On the other side, the Cardinals have consistently found ways to score, as evidenced by their 24-23 victory over the 49ers earlier in the season. Their dynamic rushing attack, led by a strong offensive line, has been a key factor in their ability to put up points. With the 49ers' defense dealing with numerous injuries, the Cardinals are well-positioned to exploit these vulnerabilities and add to the scoreboard.

Historically, matchups between these two teams have often resulted in high-scoring games. In their last three encounters, the total score has gone over the set line in two instances, indicating a pattern of offensive success. Additionally, the 49ers' recent games have seen the total score surpass the over, further supporting the likelihood of a high-scoring contest.

Given the offensive capabilities of both teams and the defensive challenges they face, the over on the total points is a compelling choice. Fans can anticipate an exciting game filled with scoring drives and big plays, as both the 49ers and Cardinals aim to conclude their seasons on a high note.

San Francisco 49ers at Arizona Cardinals Top Player Prop Picks

Joshua Dobbs Over 35.5 Rushing Yards Prop (+100) (DraftKings)

Joshua Dobbs is set to start for the 49ers in place of the injured Brock Purdy, and his mobility will be a key factor in this matchup. With the 49ers' offensive line severely depleted due to injuries, Dobbs' ability to scramble and extend plays will be crucial. Historically, Dobbs has averaged 5.5 yards per carry with seven rushing touchdowns in his career, and his recent performance against the Lions, where he scored a rushing touchdown, highlights his capability to gain significant yardage on the ground. Given the Cardinals' defensive focus on containing the pass, Dobbs is likely to exploit opportunities to run, making the over on his rushing yards a strong play.

James Conner Over 0.5 Rushing Touchdowns Prop (+120) (FanDuel)

James Conner has been a pivotal part of the Cardinals' offense, particularly in the red zone. With the 49ers' defense struggling due to injuries, Conner's ability to find the end zone becomes even more pronounced. In their previous matchup, Conner played a crucial role in the Cardinals' victory, contributing to their scoring with a two-point conversion run. The 49ers have shown vulnerabilities in their run defense, and with Conner's proven track record of scoring, betting on him to secure a rushing touchdown is a compelling option.

Deebo Samuel Over 4.5 Receptions Prop (-110) (Caesars)

Despite the 49ers' overall struggles this season, Deebo Samuel remains a reliable target in their passing game. With Joshua Dobbs under center, Samuel's role as a versatile receiver and playmaker becomes even more critical. The Cardinals' defense, while resilient, has allowed opposing receivers to find success, and Samuel's ability to create yards after the catch makes him a prime candidate to exceed the reception line. In a game where the 49ers will need to rely on quick, short passes to counteract the Cardinals' pass rush, Samuel is poised to see a high volume of targets, making the over on his receptions a favorable bet.