San Francisco 49ers at Buffalo Bills Player Props, Picks and Predictions - 12/1/2024 8:20 PM EST

We have your San Francisco 49ers at Buffalo Bills prop betting and game preview needs covered as the San Francisco 49ers hit the road to face the Buffalo Bills.

San Francisco 49ers at Buffalo Bills Odds Info

Best Moneyline Odds: San Francisco 49ers +255 (BetRivers) / Buffalo Bills -300 (BetMGM)
Best Spread Odds: -7.0 - San Francisco 49ers -110 (Caesars) / Buffalo Bills -105 (BetMGM)
Best Total Odds: 45.0 - Under -110 (BetMGM) / 44.5 - Over -110 (ESPN BET)

Special offers available for this game

Underdog: Free Pick for NEW Customers: Brock Purdy Total Yards > 0.5
Betr: Free Pick for NEW Customers: Brock Purdy Total Passing Attempts > 0.5

Game Info

Date: 12/1/2024
Time: 8:20 PM EST
Location: Highmark Stadium (Orchard Park, NY)
TV: NBC

San Francisco 49ers at Buffalo Bills Preview

The San Francisco 49ers are set to face a formidable challenge as they travel to Highmark Stadium to take on the Buffalo Bills in a highly anticipated Week 13 matchup. The Bills, boasting a 9-2 record, are riding a six-game winning streak and are eager to solidify their position atop the AFC East. Meanwhile, the 49ers, at 5-6, are fighting to keep their playoff hopes alive in a tightly contested NFC West.

Buffalo's home-field advantage is expected to be amplified by severe weather conditions, with forecasts predicting freezing temperatures, potential snowfall, and winds exceeding 20 mph. Such conditions have historically favored the Bills, who are accustomed to playing in adverse weather at Highmark Stadium. The Bills have been dominant at home, maintaining an unbeaten record this season and a remarkable 32-6 home record since 2020.

Josh Allen, the Bills' star quarterback, is in the midst of an MVP-caliber season, having thrown for 2,543 yards and 18 touchdowns with only five interceptions. His dual-threat capability is further highlighted by 316 rushing yards and five rushing touchdowns. Allen's performance will be crucial against a 49ers defense that has struggled with injuries and consistency. The 49ers' defense, which has recorded 28 sacks this season, will need to find ways to pressure Allen and disrupt his rhythm.

San Francisco enters the game with several key players potentially returning from injury, including quarterback Brock Purdy, left tackle Trent Williams, and defensive end Nick Bosa. Their availability could significantly impact the 49ers' performance, providing a much-needed boost on both sides of the ball. However, the 49ers' recent form has been concerning, with a 38-10 loss to the Green Bay Packers highlighting their vulnerabilities, particularly in the absence of their star players.

The 49ers' offense, led by backup quarterback Brandon Allen in Purdy's absence, has struggled to find consistency. Christian McCaffrey remains a focal point, but the team will need more contributions from its supporting cast to challenge a Bills defense that ranks among the league's best, allowing just 19.5 points per game.

As the 49ers look to turn their season around, they face a daunting task against a Bills team that is not only in excellent form but also well-rested coming off a bye week. The stakes are high for both teams, with the Bills aiming to clinch their fifth consecutive AFC East title and the 49ers desperate to stay in the playoff hunt. This matchup promises to be a test of resilience and adaptability, with the weather conditions adding an extra layer of intrigue to an already compelling contest.

San Francisco 49ers at Buffalo Bills Pick: Buffalo Bills Moneyline

The Buffalo Bills are poised to extend their dominance at home as they face the San Francisco 49ers in a crucial Week 13 matchup. With a 9-2 record, the Bills have been a formidable force this season, particularly at Highmark Stadium, where they boast an unbeaten record. Their home-field advantage is further bolstered by the severe weather conditions expected on game day, including freezing temperatures and strong winds, which have historically favored the Bills.

Josh Allen, the Bills' star quarterback, is having an MVP-caliber season, showcasing his dual-threat capabilities with 2,543 passing yards, 18 touchdowns, and an additional 316 rushing yards with five rushing touchdowns. Allen's ability to perform under pressure and in adverse weather conditions makes him a significant threat to the 49ers' defense, which has struggled with injuries and consistency. The Bills' offense, complemented by a strong supporting cast, has been effective in spreading the ball, with 11 different players catching touchdowns this season.

In contrast, the 49ers are grappling with a 5-6 record and are coming off a demoralizing 38-10 loss to the Green Bay Packers. Their recent form has been concerning, particularly with key players like Brock Purdy, Trent Williams, and Nick Bosa dealing with injuries. While their potential return could bolster the 49ers' lineup, the uncertainty surrounding their availability adds to the challenges San Francisco faces.

The Bills' defense, allowing just 19.5 points per game, ranks among the league's best and will be a tough test for a 49ers offense that has struggled to find consistency, especially with backup quarterback Brandon Allen at the helm. Christian McCaffrey remains a focal point, but the 49ers will need more from their supporting cast to challenge Buffalo's stout defense.

Given the Bills' current form, their home advantage, and the 49ers' injury woes, Buffalo is well-positioned to secure a victory. The Bills are not only aiming to clinch their fifth consecutive AFC East title but also to maintain their momentum as they push for a top playoff seed. With all these factors in play, the Buffalo Bills moneyline is a compelling pick for this matchup.

San Francisco 49ers at Buffalo Bills Top Player Prop Picks

Josh Allen Over 2.5 Passing Touchdowns + Rushing Touchdowns -110 (BetMGM)

Josh Allen is having an MVP-caliber season, and his dual-threat capabilities make him a formidable opponent for any defense. With 18 passing touchdowns and five rushing touchdowns already this season, Allen has been a consistent scoring threat. The 49ers' defense, while talented, has been plagued by injuries and inconsistency, as evidenced by their recent struggles against the Packers. Given the severe weather conditions expected in Buffalo, Allen's ability to adapt and perform under pressure will be crucial. His track record at home, combined with the Bills' unbeaten record at Highmark Stadium, suggests that Allen is poised to have another standout performance, making the over on his combined passing and rushing touchdowns a compelling pick.

Christian McCaffrey Over 93.5 Scrimmage Yards -115 (Caesars)

Christian McCaffrey remains a focal point of the 49ers' offense, especially with the uncertainty surrounding the availability of key players like Brock Purdy and Trent Williams. Despite the team's recent struggles, McCaffrey has consistently been a bright spot, averaging 93.7 scrimmage yards in his last three games. The Bills' defense is formidable, but McCaffrey's versatility as both a runner and receiver makes him a constant threat to accumulate yards. With the 49ers likely to lean heavily on McCaffrey to keep pace with Buffalo's high-powered offense, the over on his scrimmage yards is a strong play.

Leonard Floyd Over 0.5 Sacks +120 (FanDuel)

Leonard Floyd has been a key contributor to the 49ers' pass rush, recording 6.5 sacks this season, second only to Nick Bosa on the team. With Bosa's status uncertain due to injury, Floyd's role becomes even more critical. The Bills' offensive line will have its hands full trying to protect Josh Allen, especially in adverse weather conditions that could lead to more passing situations. Floyd's familiarity with Allen, having been his teammate last season, adds an intriguing layer to this matchup. Given the 49ers' need to disrupt Allen's rhythm to have a chance at victory, Floyd's ability to get to the quarterback makes the over on his sack total an enticing proposition.