Here is the Pickwatch BetSmart Preview for the Seattle Seahawks @ Arizona Cardinals in Week 4 of the 2025 NFL Season.

Seahawks vs. Cardinals Game Info

Date: Thursday, September 25, 2025
Time: 5:15 PM PT (8:15 PM ET)
Location: State Farm Stadium — Glendale, Arizona
TV: Amazon Prime Video / Thursday Night Football broadcast

Seahawks vs. Cardinals Betting Odds

Point Spread
- Seahawks -1.5 (-110)
- Cardinals +1.5 (-110)
Moneyline
- Seahawks -126
- Cardinals +108
Total
- Over 43.5 (-105)
- Under 43.5 (-115)

*Odds via FanDuel

Seattle Seahawks (2–1) @ Arizona Cardinals (2–1) Preview

The Seahawks head into Thursday night with momentum after a dominant 44–13 win over New Orleans, while Arizona fell short in a nail-biting 16–15 loss to San Francisco. Seattle has quietly been strong this season, particularly on defense, and they lead the all-time series 29–22–1.

Arizona will be without their lead back James Conner, who is out for the season after an ankle injury, weakening an already thin offense. The Cardinals have also placed CB Garrett Williams and DL L.J. Collier on IR, increasing stress on their secondary.

Seattle faces injury concerns too: CB Devon Witherspoon, safety Julian Love, and RB Zach Charbonnet have been listed as doubtful in recent reports. With a short week for prep, both teams may lean more on established schemes; the market has tilted Seattle –1.5 with a low total of 43.5, suggesting a defensive, close game.

Head-to-Head Stats and Analysis

Their most recent matchup was December 8, 2024 at State Farm Stadium, where Seattle won 30–18.

Seahawks 30, Cardinals 18 (2024)
Cardinals 6, Seahawks 16 (2024)
Seahawks 21, Cardinals 20 (2024)
Cardinals 10, Seahawks 20 (2023)
Seahawks 31, Cardinals 21 (2022)

BetSmart Betting Rundown

The Pickwatch BetSmart subscription package provides valuable sports betting tools to help you wager wisely and build bankroll. Sign up for a 14-Day Free Trial today and get instant access to our proprietary tools and data.

Arbitrage

Our Arbitrage Betting Tool currently does not show any arbitrage bets available for this game. The tool scans all major sportsbooks in real-time, however, so be sure to check back often as odds and lines change often, and an arbitrage opportunity could become available before kickoff.

Middles

Our Middle Betting Tool has identified 18 different middle betting opportunities, many of which are among some of the Most Profitable Markets so far this season.

Positive EV

Our Positive EV Betting Tool has identified 8 different positive expected value wagers, and provided data on the expected value percentrage, suggested Kelly Stake, and how often the bet has hit in the last 5, 10 and 15 games.

Player Props

Our Prop Finder Tool has identified 57 different player prop bets, and provided data on how often each player has hit the specific prop in the last 5, 10 and 15 games.

Season Betting Records

Moneyline
- Seahawks: 2-1
- Cardinals: 2-1
Against the Spread
- Seahawks: 2-1
- Cardinals: 2-1
Totals (Over-Under)
- Seahawks: 2-1
- Cardinals: 1-2

Seahawks vs. Cardinals: Expert Picks

Visit our Expert Picks page to view picks and data from over 200 experts to see where the consensus is on the Seahawks vs. Cardinals moneyline, point spread and total points.