USC Trojans @ Purdue Boilermakers Player Props, Picks and Predictions - 9/13/2025 3:30 PM EDT

We have your USC Trojans @ Purdue Boilermakers prop betting and game preview needs covered as the USC Trojans hit the road to face the Purdue Boilermakers.

USC Trojans @ Purdue Boilermakers Pick

Best Moneyline Odds: USC -1600 (Caesars), Purdue +1000 (ESPN BET)
Best Spread Odds: USC -21.0 (-110) at Caesars, Purdue +21.5 (-110) at BetRivers
Best Total Odds: Over 58.5 (-110) at FanDuel, Under 58.5 (-105) at ESPN BET

Game Info

Date: September 13, 2025
Time: 3:30 PM EDT
Location: Ross-Ade Stadium, West Lafayette, Indiana
TV: -

USC Trojans @ Purdue Boilermakers Preview

The USC Trojans, currently holding a perfect 2-0 record, are set to embark on their first road trip of the season and their inaugural Big Ten conference game against the Purdue Boilermakers, who also stand at 2-0. USC is coming off a dominant 59-20 victory over the Georgia Southern Eagles, showcasing their high-octane offense under coach Lincoln Riley.

Quarterback Jayden Maiava has been a revelation, looking like the next successful signal-caller in Riley's system. Through two games, Maiava has amassed 707 passing yards, six touchdowns, and zero interceptions, boasting an impressive 73.8% completion rate. His top targets, wide receivers Makai Lemon (248 yards, 2 TDs) and Ja’Kobi Lane (124 yards, 2 TDs), have been instrumental in USC's early leads. The Trojans' ground game is equally potent, with Waymond Jordan, King Miller, and Eli Sanders combining for 542 rushing yards and 10 touchdowns.

While USC's offense has been firing on all cylinders, their defense, led by linebacker Eric Grentry (13 total tackles, 1 sack) and safety Bishop Fitzgerald (10 total tackles, 1 INT TD), has shown flashes of brilliance but also moments of sloppiness. Cleaning up these mistakes will be crucial as they enter Big Ten play.

The Purdue Boilermakers, under quarterback Ryan Browne, have also started strong. Browne has thrown for 481 yards, four touchdowns, and one interception, adding 55 rushing yards and a touchdown with his legs. Running back Devin Mockobee leads Purdue's rushing attack with 185 yards and three touchdowns on 46 carries. Purdue will be looking to turn things around after finishing last in the Big Ten last season, and a home game against a high-profile opponent like USC presents a significant opportunity.

Historic Head-to-Head Stats and Analysis

Specific historical head-to-head game results between the USC Trojans and Purdue Boilermakers are not available in the provided research. However, the context of this matchup is significant. For USC, this marks their first Big Ten conference game on the road, a scenario where they experienced a loss to Maryland last season. Purdue, on the other hand, finished last in the Big Ten in the previous season and will be eager to make a statement at home against a top-tier opponent.

Pick: Over 58.5 Total Points

This matchup has all the makings of a high-scoring affair. The USC Trojans' offense has been incredibly efficient and explosive, averaging a staggering 66 points per game through their first two contests. Quarterback Jayden Maiava is in top form, and their diverse rushing attack can exploit various defensive weaknesses. While Purdue's defense has shown some early season solidity, their performance last season, ranking 125th in yards allowed and 132nd in points allowed, suggests they could be vulnerable to USC's firepower.

Purdue's offense, averaging 32.5 points per game, also contributes to the potential for a high total. With quarterback Ryan Browne capable of both passing and running, and Devin Mockobee leading a respectable ground game, the Boilermakers should be able to put up points, especially at home. Given the combined offensive output of both teams and USC's occasional defensive lapses, betting the Over on 58.5 total points appears to be a strong play.

Top Player Prop Picks

Jayden Maiava (USC QB) Over Passing Yards

USC quarterback Jayden Maiava has been exceptional to start the season, averaging 353.5 passing yards per game. His command of Lincoln Riley's offense, coupled with a 73.8% completion rate and no interceptions, indicates he's poised for continued success. While Purdue's pass defense is currently ranked 29th, USC's offensive scheme and Maiava's talent are designed to exploit any vulnerabilities. Expect Maiava to continue airing it out and exceeding his average in this matchup.

USC Team Over Rushing Yards

The USC Trojans' rushing attack has been incredibly productive, accumulating 542 total yards and 10 touchdowns across their first two games, averaging 271 rushing yards per contest. With a trio of talented running backs in Waymond Jordan, King Miller, and Eli Sanders, USC can wear down defenses. Purdue's rush defense is currently ranked 47th, but the sheer volume and efficiency of USC's ground game suggest they will surpass their team rushing total in this game.

Devin Mockobee (Purdue RB) Over Rushing Yards

Devin Mockobee is Purdue's leading rusher, averaging 92.5 yards per game through two contests. While USC's rush defense is ranked 51st, Purdue will likely lean on Mockobee to establish their presence at home and control the clock against a high-powered USC offense. If the Boilermakers can find early success on the ground, Mockobee has the potential to exceed his average and be a key factor in Purdue's offensive strategy.