Villanova Wildcats @ Penn State Nittany Lions Player Props, Picks and Predictions - 9/13/2025 3:30 PM EDT

We have your Villanova Wildcats @ Penn State Nittany Lions prop betting and game preview needs covered as the Villanova Wildcats hit the road to face the Penn State Nittany Lions.

Game Info

Date: 9/13/2025
Time: 3:30 PM EDT
Location: Beaver Stadium, University Park, PA
TV: BTN

Villanova Wildcats @ Penn State Nittany Lions Preview

The Penn State Nittany Lions, currently ranked No. 2 in the AP Top 25 poll, are set to host the Villanova Wildcats in what is expected to be a dominant performance. Penn State enters this matchup with a 2-0 record, having secured a resounding 34-0 victory over FIU and a 46-11 win against Nevada in their season opener. Their defense has been stifling, allowing only 5.5 points per game (ranked 8th nationally) and holding opponents to just 3.98 yards per play (ranked 25th). On offense, led by potential 2026 NFL Draft top-5 pick Drew Allar, the Nittany Lions are averaging 40.0 points per game. Allar was highly efficient in Week 1, completing 85% of his passes for 217 yards. While their rushing attack is still finding its rhythm, Penn State's overall offensive output of 6.27 yards per play (ranked 56th) indicates their ability to move the ball effectively.

The Villanova Wildcats, on the other hand, face a significant challenge on the road. They come into this game with an 0-1 record, having scored 17 points in their last outing while giving up 38 points. Historically, Villanova has struggled away from home, holding a 1-13 straight-up record in their last 14 road games and a 1-9 straight-up record in their last 10 September games. Their offense has managed 280 total yards per game, with 58 rushing yards and 222 passing yards. Defensively, they have allowed 509 total yards, including 429 passing yards, which could be exploited by Penn State's passing game.

Historic Head-to-Head Stats and Analysis

The Penn State Nittany Lions hold a perfect 2-0 all-time record against the Villanova Wildcats. Both of these victories have come at home for Penn State. In their most recent encounter on September 25, 2021, Penn State defeated Villanova 38-17. While Penn State secured the straight-up win, Villanova managed to cover the spread of +29.5 in that contest. Overall, Villanova holds an 0-2 Against The Spread (ATS) record in their head-to-head matchups with Penn State.

Pick: Penn State Nittany Lions Spread

While specific betting lines for this game are not yet available, all indications point to a dominant performance by the Penn State Nittany Lions. Ranked No. 2 nationally and coming off impressive victories, Penn State is expected to be an overwhelming favorite. Their stifling defense, which ranks among the nation's best in points allowed and yards per play, combined with an efficient offense led by Drew Allar, positions them well to control this game from start to finish. Given Villanova's struggles on the road and historically against Penn State, the Nittany Lions are poised to win by a significant margin and cover what is anticipated to be a large spread.